T1 mapping in population ageing

Abstract Funding Acknowledgements Type of funding sources: None. Background The world’s population is ageing: every country experiencing growth in both the size and proportion older people. Common health states age mainly include cardiovascular disease. To ensure that our system ready to face this demographic shift, we investigated native post-contrast T1 mapping as a quantitative method appraise its clinical potential Purpose This article aimed provide reference values for quantification expansion extracellular matrix Methods We retrospectively selected subjects ranged from 86 101 years old underwent contrast cardiac magnetic resonance (CMR). All were imaged on 1.5 T system. measurements performed with Modified Look Lockers Inversion (MOLLI) recovery sequence. Regions interest (ROI) drawn left ventricle blood measurement interventricular septum. used data obtained before after injection. also measured volume function ventricles. Rho di Spearman was correlations. Results analysed 29 patients (mean 88.58±3.13 old). Mean value pool (T1bp) 1647.43±107.66 357.18±63.94 contrast. septum (T1s) 1012.86±38.41 488.68±69.29 Left (LV) EDVI 48.11±15.29 ml/m2 ESVI 16.49±8.59 ml/m2, LV ejection fraction (EF) stroke (SV) 66.38±9.65 % 52.39±18.84 ml respectively. Right (RV) 46.44±13.19 16.97±5.93 63.46±8.65 49.29±18.63 A significant negative correlation found between T1s (r=-0.405 p = 0.015). Positive correlations volumes. Conclusions study shows ageing.